The Engine for Regenerative Medicine (NCERM) is a comprehensive initiative led by the Wake Forest Institute for Regenerative Medicine (WFIRM) in Winston Salem, NC. Aimed at addressing the escalating healthcare costs in the U.S., NCERM focuses on regenerative medicine (RM) to provide therapeutic solutions addressing the root causes of diseases. Collaborating with the Regenerative Medicine Development Organization (ReMDO), NCERM works to establish a robust regional innovation ecosystem, leveraging WFIRM's expertise and success in translating scientific discoveries into clinical therapies. With the global RM market projected to reach $125 billion by 2030, NCERM aims to tackle challenges hindering the field's progress, including workforce development, job creation, and economic growth. The initiative recognizes the decline of traditional industries in the region, such as tobacco and textiles, and aims to capitalize on WFIRM's reputation to establish a new biomanufacturing economy. Leveraging spaceflight expertise gained through collaborations with NASA and Axiom Space, NCERM intends to accelerate RM initiatives and attract investment. The proposal emphasizes collaboration, mentorship, and addressing technical challenges, intending to propel the regenerative medicine industry forward and contribute to global advancements in the field while fostering economic development in central North Carolina.